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张斌       1975年出生，理学博士。1996年和1999年于武汉大学分别获得病毒与分子生物学学士和硕士学位，2002年于北京协和医科大学获得生化与分子生物学博士学位。2003年赴美国University of Alabama at Birmingham 进行博士后研究工作，2004年转入Medical College of Georgia。2009年转为Assistant Research Scientist。在美期间主要从事神经肌肉接头形成发育的分子机制，以及神经肌肉接头相关的神经疾病的发病机理研究，并在Neuron、Journal of Neuroscience、Journal of Clinical Investigation、Archive of Neurology等国际学术刊物上发表多篇论文，研究工作被Nature、Science、Neuron、Nature Reviews Neuroscience等学术刊物引用，其中对于LRP4蛋白在神经肌肉接头形成中重要作用的研究成果已被Principles of Neural Science (Kandel et al., 5th edition)， Fundamental Neuroscience (Squire et al., 4th edition) 等权威神经生物学教科书收录。2013年12月回国工作，受聘为华中科技大学基础医学院生理学系教授。

研究方向:

以神经肌肉接头为模型研究神经突触形成发育的分子机制

神经肌肉接头相关的神经疾病的发病机理

联系方式：

华中科技大学同济医学院

基础医学院2号楼1621室

Email： zhangbin@mails.tjmu.edu.cn

主要学术论文：

1.Lei Li*, Yu Cao*, Haitao Wu, Xinchun Ye, Zhihui Zhu, Guanglin Xing, Chengyong Shen, Arnab Barik, Bin Zhang, Xiaoling Xie, Wenbo Zhi, Lin Gan, Huabo Su, Wen-Cheng Xiong, Lin Mei. Enzymatic Activity of the Scaffold Protein Rapsyn for Synapse Formation. Neuron. 92(5):1007-1019, 2016. *, equal contributing authors.

2.Chao Shi, Xuan Huang, Bin Zhang, Dan Zhu, Huqiao Luo, Quqin Lu, Wen-Cheng Xiong, Lin Mei, Shiwen Luo. The Inhibition of Heat Shock Protein 90 Facilitates the Degradation of Poly-Alanine Expanded Poly (A) Binding Protein Nuclear 1 via the Carboxyl Terminus of Heat Shock Protein 70-Interacting Protein. PLoS One. 10(9):e0138936, 2015.

3.Robert P. Lisak, Bin Zhang, Chengyong Shen, Lin Mei. Neuromuscular junction as Achilles' heel: yet another autoantibody? Neurology. 84(2):214-5, 2015.

4.Arnab Barik, Bin Zhang, Gurkirpal S. Sohal, Wen-Cheng Xiong, Lin Mei. Crosstalk between Agrin and Wnt signaling pathways in development of vertebrate neuromuscular junction. Dev Neurobiol. 74(8):828-38, 2014

5.Bin Zhang*, Chengyong Shen*, Beverly Bealmear, Samia Ragheb, Wen-Cheng Xiong, Richard A. Lewis, Robert P. Lisak, Lin Mei. Autoantibodies to agrin in myasthenia gravis patients. PLoS One. 9(3):e91816, 2014. *, equal contributing authors.

6.Chengyong Shen^※, Yisheng Lu^※,Bin Zhang^※, Dwight Figueiredo, Jonathan Bean, Jiung Jung, Haitao Wu, Arnab Barik, Dong-Min Yin, Wen-Cheng Xiong and Lin Mei. Immunization with LRP4 induces myasthenia gravis in mice. J Clin Invest. 123(12):5190-202, 2013. ^※,equal contributing authors.

7.Bin Zhang, Chuan Liang, Ryan Bates, Yiming Yin, Wen-Cheng Xiong, Lin Mei. Wnt proteins regulate acetylcholine receptor clustering in muscle cells. Mol Brain. 5:7, 2012.

8.Yinong Zong, Bin Zhang, Shenyan Gu, Kwangkook Lee, Jie Zhou, Guorui Yao, Dwight Figueiredo, Kay Perry, Lin Mei, Rongsheng Jin. Structural basis of agrin-LRP4-MuSK signaling. Genes Dev. 26(3): 247-58, 2012

9.Bin Zhang, John S. Tzartos, Maria Belimezi, Samia Ragheb, Beverly Bealmear, Richard A. Lewis, Wen-Cheng Xiong, Robert P. Lisak, Socrates J. Tzartos, Lin Mei. Autoantibodies to Lipoprotein-Related Protein 4 in patients with double-seronegative myasthenia gravis. Arch Neurol. 69(4):445-51, 2012. Epub 2011 Dec

 10.Fei Xiong, Sergey Leonov, Amber Cyan Howard, Shan Xiong, Bin Zhang, Lin Mei, Paul McNeil, Sylvia Simon, Wen-Cheng Xiong. Receptor for Advanced Glycation End Products (RAGE) prevents endothelial cell membrane resealing and regulates  F-actin remodeling in a β-Catenin-dependent Manner. J. Biol. Chem. 286: 35061-70, 2011.

11.Shi-wen Luo, Chun Zhang, Bin Zhang, C-H. Kim, Y-Z. Qiu, Lin Mei, and Wen-Cheng Xiong. Regulation of heterochromatin remodeling and myogenin expression by FAK interaction with MBD2. EMBO J, 28(17): 2568-82, 2009.

12.Bin Zhang, Shi-wen Luo, Qiang Wang, Tatsuo Suzuki, Wen-Cheng Xiong, Lin Mei. LRP4 serves as a coreceptor of agrin. Neuron. 60(2):285-97, 2008 .

13.Shi-wen Luo, Bin Zhang, Xian-ping Dong, Yanmei Tao, Annie Ting ,Zheng Zhou, James Meixiong, Junjie Luo, F.C. Alex Chiu, Wen C. Xiong, Lin Mei. HSP90 beta regulates rapsyn turnover and subsequent AChR cluster formation and maintenance. Neuron. 60(1):97-110, 2008

14.Xiao-Ming Li*, Xian-Ping Dong*, Shi-Wen Luo, Bin Zhang, Dae-Hoon Lee, Annie K L Ting, Hannah Neiswender, Chang-Hoon Kim, Ezekiel Carpenter-Hyland, Tian-MingGao, Wen-Cheng Xiong, Lin Mei. Retrograde regulation of motoneuron differentiation by muscle β-catenin. Nat Neurosci. 11(3):262-8, 2008. *, equal contributing authors.

15.Qiang Wang*, Bin Zhang*, Ye Elaine Wang, Wen-Cheng Xiong, Lin Mei. The Ig1/2 domain of MuSK binds to muscle surface and is involved in acetylcholine receptor clustering. Neurosignals. 16(2-3):246-53, 2008. *, equal contributing authors

16. Bin Zhang*, Shi-wen Luo*, Xian-Ping Dong*, Xian Zhang, Chunming Liu, Zhenge Luo, Wen-Cheng Xiong, Lin Mei. β-Catenin regulates AChR clustering in muscle cells through interaction with rapsyn. J. Neurosci. 27:3968-73, 2007. *, equal contributing authors

文献综述:

1. Bin Zhang, Wen-Cheng Xiong, Lin Mei. Get ready to Wnt: prepatterning in neuromuscular junction formation. Dev Cell. 16(3):325-7, 2009.

2. G. C. Dobbins, Bin Zhang, Wen C. Xiong, and Lin Mei. The role of the cytoskeleton in neuromuscular junction formation. J. Mol. Neurosci. 30:115-118, 2006.

3. Qiang Wang, Bin Zhang, Wen-Cheng Xiong, and Lin Mei. MuSK signalings at the neuromuscular junction. J. Mol. Neurosci. 30:223-226, 2006.