孙书国，博士生导师，教授，任基础医学院解剖学系主任，武汉解剖学会会长。孙书国团队长期从事Hippo信号通路和肺癌的发生、发展和肿瘤免疫方面的研究。以第一或通讯作者在Cell、Molecular Cell、Trends Cell Biology、Nature Communications等发表了多篇有影响力的论文多篇。获得国家自然科学基金委、科技部重点研发计划等多项研究项目的支持。
研究方向一：Hippo信号通路与肺癌。
研究方向二：肺癌驱动基因的鉴定和功能机制研究。
研究方向三：肺癌的肿瘤免疫学
联系方式：shuguo@hust.edu.cn
近年发表的主要论著：（通讯作者#）
1 Rauskolb, C. *, Sun, S.*, Sun, G., Pan, Y. & Irvine, K. D. # Cytoskeletal tension inhibits Hippo signaling through an Ajuba-Warts complex. Cell158, 143-156, doi:10.1016/j.cell.2014.05.035 (2014).
2 Sun, S. * G., Reddy, B. V. V. G. & Irvine, K. D. # Localization of Hippo signalling complexes and Warts activation in vivo. Nature Communications6, doi:Artn 840210.1038/Ncomms9402 (2015).
3 Sun, S. *& Irvine, K. D. # Cellular Organization and Cytoskeletal Regulation of the Hippo Signaling Network. Trends Cell Biol26, 694-704, doi:10.1016/j.tcb.2016.05.003 (2016).
4 Mao, Y. *, Sun, S. *& D. Irvine, K#. Role and Regulation of Yap in KrasG12D-induced lung cancer. Oncotarget, doi:10.18632/oncotarget.22865 (2017).
5 Yu, M. *, Zhengxin Peng*, et alShuguo Sun#. Interferon-γ induces tumor resistance to anti-PD-1 immunotherapy by promoting YAP phase separation. Molecular Cell, doi:https://doi.org/10.1016/j.molcel.2021.01.010 (2021).
6 Zhengxin Peng*, Man Yu*, et al Shuguo Sun#.Establishlung adenocarcinoma immunotherapy allograft model and analysis of the tumor response by flow cytometry and immunofluorescence. Star Protocol 2021 invited protocol (in press)
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