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李岩，华中科技大学同济医学院教授，博士生导师，人畜共患传染病重症诊治全国重点实验室PI，同济医院双聘教授，病原生物学系党支部书记，国家高层次青年人才，湖北省杰青，湖北省公共卫生青年拔尖人才。目前担任教育部病毒学领域教学资源建设项目专家、Wiley出版社VIEW Medicine副主编、Journal of Cellular Biochemistry编委、Military Medical Research青年编委以及The BMJ等二十余个期刊审稿人。于中国科学技术大学获得学士学位，新加坡南洋理工大学获得博士学位，在新加坡科技研究局试验治疗中心从事多年的新药研究工作。

课题组利用生物化学、分子生物学、结构生物学、人工智能、微生物学等多种方法探究包括新冠病毒、利什曼原虫在内等重要病原微生物致病的分子机制，并针对性的开发新型的干预手段。目前课题组参与的多个新药研发项目已经进入临床试验阶段，以（共同）通讯作者/第一作者在Science、Lancet Microbe、Nucleic Acids Research、Journal of Infection、Nature Communications、Journal of Virology等期刊发表SCI论文30余篇，H因子24。参编高等教育出版社及科学出版社医学微生物学多本教材。申请药物专利多项，参与的多个新药研发项目进入临床试验阶段。主持国家自然科学基金新冠专项项目及面上项目、湖北省杰出青年基金、多个公司合作课题、武汉市卫健委应急科研专项等多个项目，作为骨干成员参与多个国家重点研发计划、湖北省创新研究群体等。

代表性文章：

#Co-first author *Corresponding author

1. Zhang, H.#, Lv, P.#, Jiang, J., Liu, Y., Yan, R., Shu, S., Hu, B.,Xiao, H.,Cai, K.,Yuan,S.*,&Li, Y.* (2023).Advances in developing of ACE2 derivatives against SARS-CoV-2.The Lancet Microbe,4(5), e369-e378.

2. He, Z.,Ke, Z., Wang, W., Liu, Y., Zhang, H.*, &Li, Y.*(2023). Biophysical and biochemical characterization of the binding of the MarR-like transcriptional regulator Saro_0803 to thenov1promotor and its inhibition by resveratrol.Biomolecules, 13(3), 541.

3. Zhang, H.#, Hu, B.#, Lv, P.#, Liu, Y.#, Guo, M., Wu, Z., Zhou, K., Dai, M., Yu, X., Liu, Z., Yu, B., Xu, L., Guo, M.*, Cai, K.*,&Li, Y.* (2022).An ACE2-mimicking decoy inhibitor effectively neutralizes SARS-CoV-2 Omicron BA.5 variant.Viruses, 14(11),2387.

4. Lv, P.#, Hu, B.#, Hua, R.#, Zhang, J.#,Zhang, H., Liu, Z., Xu, L., He, Z., Li, X., Guo, M., Pan, K., Zhang, Z., Zeng, Q., Wu, Z., Sun, L., Guo, M., Zhou, L., Xu, X., Yu, B., Xu, J., Yuan, S., Guo, M.*, Cai, K.*, Xia, Y.*,&Li, Y.* (2022).A novelly designed protein antagonist confers potent neutralization against SARS-CoV-2 variants of concern.Journal of Infection,85(3), e72-e76.

5. Zhao, K.#, Ke, Z.#, Hu, H.#, Liu, Y., Li, A., Hua, R., Guo, F., Xiao, J., Zhang, Y., Duan, L, Yan, X., Gao, Y., Liu, B., Xia, Y.*,&Li, Y.* (2021). Structural basis and function of the N-terminus of SARS-CoV-2 nonstructural protein 1.Microbiology Spectrum, 9(1), e00169-21.

6. Xu, C.#, Ke, Z.#, Liu, C.#, Wang, Z.#, Liu, D., Zhang, L., Wang, J., He, W., Xu, Z., Li, Y., Yang, Y., Huang, Z., Lv, P., Wang, X., Han, D.*,Li, Y.*, Qiao, N.*,&Liu, B.* (2020). Systemicin silicoscreening in drug discovery for coronavirus disease (COVID-19) with an online interactive web server.Journal of Chemical Information and Modeling,60(12), 5735-5745.

7. Lau, Q.#, Li, J.#,Sani, M.#, Sinha, S.#,Li, Y.#, Ng, F., Kang, C., Bhattacharjya, S., Separovic, F., Verma, C., & Chia, C.* (2018). Elucidating the bactericidal mechanism of action of the linear antimicrobial tetrapeptide BRBR-NH₂.Biochimica et Biophysica Acta (BBA) - Biomembranes,1860(8), 1517-1527.

8. Li, Y.#, Zhang, Z.#, Phoo, W.#, Loh, Y., Li, R., Yang, H., Jansson, A., Hill, J., Keller, T., Nacro, K.*, Luo, D.*, & Kang, C.* (2018). Structural insight into the inhibition of Zika virus NS2B-NS3 protease by a small-molecule inhibitor.Structure, 26(4), 555-564.e3.

9. Li, Y., Lee, M., Loh, Y., & Kang, C.* (2018). Secondary structure and membrane topology of Dengue Virus NS4A protein in micelles.Biochimica et Biophysica Acta (BBA) - Biomembranes, 1860(2), 442-450.

10. Li, Y.#, Zhang, Z.#, Phoo, W., Loh, Y., Wang, W., Liu, S., Chen, M., Hung, A., Keller, T., Luo, D.*, & Kang, C.* (2017). Structural dynamics of Zika virus NS2B-NS3 protease binding to dipeptide inhibitors.Structure, 25(8), 1242-1250.e3.

11. Zhang, Z.#,Li, Y.#, Loh, Y., Phoo, W., Hung, A., Kang, C.*, & Luo, D.* (2016). Crystal structures of unlinked NS2B-NS3 protease from Zika Virus.Science, 354(6319), 1597-1600.

12. Phoo, W.#,Li, Y.#, Zhang, Z., Lee, M., Loh, Y., Tan, Y., Ng, E., Lescar, J., Kang, C.*, & Luo, D.* (2016).Structureof the NS2B-NS3 protease from Zika virus after self-cleavage.Nature Communications, 7, 13410.

13. Li, Y.,Wong, Y., Lee, M., Li, Q., Wang, Q., Lescar, J., Shi, P., & Kang, C.* (2016). Secondary structure and membrane topology of the full-length Dengue Virus NS4B in micelles.Angewandte Chemie International Edition, 55(39), 12068-12072.

14. Li, Y., Wong, Y., Ng, F., Liu, B., Wong, Y., Poh, Z., Liu, S., Then, S., Lee, M., Ng, H., Huang, Q., Hung, A., Cherian, J., Hill, J., Keller, T., & Kang, C.* (2016).Escherichia colitopoisomerase IV E subunit and an inhibitor binding mode revealed by NMR spectroscopy.Journal of Biological Chemistry, 291(34), 17743-17753.

15. Li, Y.#, Li, Q.#, Wong, Y., Liew, L., & Kang, C.* (2015). Membrane topology of NS2B of dengue virus revealed by NMR spectroscopy.Biochimica et Biophysica Acta (BBA) - Biomembranes, 1848(10 Pt A), 2244-2252.

16. Li,Y.#, To,J.#,Verdia-Baguena,C.#, Dossena,S.,Surya, W., Huang, M.,Paulmichl,M.,Liu, D.,Aguilella, V.,&Torres,J.*(2014).Inhibition of thehumanrespiratorysyncytialvirussmallhydrophobicprotein andstructuralvariations in abicelleenvironment.Journal of Virology, 88(20), 11899-11914.

17. Li, Y.#, Surya, W.#, Claudine, S., & Torres, J.* (2014).Structure of a conserved Golgi complex-targeting signal in coronavirus envelope proteins.Journal of Biological Chemistry,289(18),12535-12549.

18. Wong, L.#,Li, Y.#, Pillay, S., Frolova, L., & Pervushin, K.* (2012). Selectivity of stop codon recognition in translation termination is modulated by multiple conformations of GTS loop in eRF1.Nucleic Acids Research, 40(12), 5751-5765.