胡清华，华中科技大学同济医学院病理生理学系主任，教授，博士生导师；华中学者特聘教授；卫生部呼吸疾病重点实验室副主任；中国病理生理学会缺氧与呼吸专业委员会主任委员；中国生理学会呼吸专业委员会主任委员；国家自然科学基金委员会专家评审组成员。1989年毕业于同济医科大学临床医学系，获学士学位；1994年获同济医科大学博士学位，并留校任教讲师。1996年赴美国约翰霍普金斯大学医学院做博士后研究，并相继于2000年晋升为Instructor，2002年晋升为Assistant Professor。2004年兼任华中科技大学同济医学院讲座教授，2007年全职回国工作。
致力于呼吸与循环系统疾病，包括肺动脉高压的基础和临床相关研究。系列论文发表于国际学术期刊包括Lancet、Circulation、Circulation Research、J Biol Chem、J Cell Sci、Antioxid Redox Signal、Hypertension等。其研究工作获得国家自然科学基金委员会(八次，包括重点、国际交流合作项目)、美国心脏学会(AHA，两次)和美国国立卫生研究院(NIH，一次)的连续资助。曾获美国医学研究联合会(American Federation for Medical Research)颁发的Henry Christian奖，并担任美国心脏学会(AHA)和英国The Wellcome Trust基金会研究项目评审专家，国内外期刊American Journal of Respiratory Cell and Molecular Biology、Circulation、Circulation Research等的审稿人。
Xiao R, Luo S, Zhang T, Lv Y, Wang T, Zhang J, Su Y, Ruiz M, Dupuis J, Zhu L*,Hu Q*. Peptide blocking self-polymerization of extracellular calcium-sensing receptor attenuates hypoxia-induced pulmonary hypertension.Hypertension. 2021;78(5):1605-1616.(IF=10.190)
Zhu L, Liu F, Hao Q, Feng T, Chen Z, Luo S, Xiao R, Sun M, Zhang T, Fan X, Zeng X, He J, Yuan P, Liu J, Ruiz M, Dupuis J,Hu Q*. Dietary geranylgeranyl pyrophosphate counteracts the benefits of statin therapy in experimental pulmonary hypertension.Circulation. 2021;143(18):1775-1792. (IF=23.603)
Xiao R, Zhu L, Su Y, Zhang J, Lu Y, Li J, Wang T, Fang J, Jing ZC, Dupuis J, Luo S,Hu Q*. Monocrotaline pyrrole induces pulmonary endothelial damage through binding to and release from erythrocytes in lung during venous blood reoxygenation.Am J Physiol Lung Cell Mol Physiol. 2019;316(5):L798-L809. (IF=4.418)
Zhu L#, Xiao R#, Zhang X, Lang Y, Liu F, Yu Z, Zhang J, Su Y, Lu Y, Wang T, Luo S, Wang J, Liu ML, Dupuis J, Jing ZC, Li T, Xiong W,Hu Q*. Spermine on endothelial extracellular vesicles mediates smoking-induced pulmonary hypertension partially through calcium-sensing receptor.Arterioscler Thromb Vasc Biol. 2019, 39(3):482-495. (IF=6.618)
Zeng X#, Zhu L#*, Xiao R, Liu B, Sun M, Liu F, Hao Q, Lu Y, Zhang J, Li J, Wang T, Wei X,Hu Q*. Hypoxia-induced mitogenic factor acts as a non-classical ligand of calcium-sensing receptor, therapeutically exploitable for hypoxic pulmonary hypertension.Hypertension. 2017, 69(5):844-854. (IF=7.017)
Xiao R#, Su Y#, Feng T, Sun M, Liu B, Zhang J, Lu Y, Li J, Wang T, Zhu L*,Hu Q*. Monocrotaline induces endothelial injury and pulmonary hypertension by targeting the extracellular calcium-sensing receptor.J Am Heart Assoc. 2017, 6(4): e004865.(IF=4.660)
Su Y#, Zhu L#, Yu X#, Cai L#, Lu Y, Zhang J, Li T, Li J, Xia J, Xu F*,Hu Q*. Mitochondrial transplantation attenuates airway hyperresponsiveness by inhibition of cholinergic hyperactivity.Theranostics. 2016, 6(8): 1244-1260. (IF= 8.854)
Chen F#,Zhu L#, Cai L, Zhang J, Zeng X, Li J, Su Y,Hu Q*. A stromal interaction molecule 1 variant up-regulates matrix metalloproteinase-2 expression by strengthening nucleoplasmic Ca2+signaling. Biochim Biophys Acta-Mol Cell Res. 2016, 1863(4): 617-629. (IF= 5.128)
Tan R#, Li J#, Peng X, Zhu L, Cai L, Wang T, Su Y, Irani K,Hu Q*. GAPDH is critical for superior efficacy of female bone marrow-derived mesenchymal stem cells on pulmonary hypertension.Cardiovasc Res. 2013, 100(1): 19-27.(IF= 5.940)
Zhang J#, Zhou J#, Cai L, Lu Y, Wang T, Zhu L,Hu Q*. Extracellular calcium-sensing receptor is critical in hypoxic pulmonary vasoconstriction.Antioxid Redox Signal. 2012, 17(3): 471-484. (IF= 8.456)
Zhu L#, Song S#, Pi Y, Yu Y, She W, Ye H, Su Y,Hu Q*. Cumulated Ca2+spike duration underlines Ca2+oscillation frequency-regulated NF-kB transcriptional activity.J Cell Sci.2011, 124: 2591-2601. (IF= 6.111)
1.美国医学研究联合会(American Federation for Medical Research)颁发的研究奖，1998，Henry Christian Award
2. Finalist for Basic Research Award Research Retreat, 2004, Johns Hopkins University School of Medicine
3. 2005年，缺氧性肺血管收缩反应特征机制和调控的系统究，湖北省自然科学奖三等奖
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